Instrumental Analysis of Tetrodotoxin
نویسندگان
چکیده
منابع مشابه
Interactions of the C-11 hydroxyl of tetrodotoxin with the sodium channel outer vestibule.
The highly selective sodium channel blocker, tetrodotoxin (TTX) has been instrumental in characterization of voltage-gated sodium channels. TTX occludes the ion-permeation pathway at the outer vestibule of the channel. In addition to a critical guanidinium group, TTX possesses six hydroxyl groups, which appear to be important for toxin block. The nature of their interactions with the outer vest...
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